Skip to main content

Capping Tablet and its solution

The cases of tablet failure can be separated into two kinds: capping and lamination. In the case of biconvex tablets, capping corresponds to the separation of at least one of the two cups of the tablets whereas lamination corresponds to a failure in the band of the tablet. This article is focused on capping and its solution.

Capping is the upper or lower segment of the tablet separates horizontally, either partially or completely from the main body, and comes off like a cap, during ejection from the tablet press, or during subsequent handling. The common factors which can cause tablet capping; formulation related, excipient-related and machine-related.

Major causes of capping tablet and remedies for them

1. Fines

This is the matter faced within the formulation of the granules. Fines are small dust particles that are found within the tablets. These particles don't compress or flow alright and as a result, the tablet faces many problems.


Capping in Tablets

Cause: the variety of fines within the granules are quite the traditional amount. If the quantity of fines increases within the granules, it can further end in weight variation and segregation during compression of the tablet. this may cause improper flow or may be blockage of the flow of air.

Remedies: you would like to get rid of all or a number of the fines by using 100 to 200 mesh screens. By removal of fine particles, the air will flow properly within the tablet and therefore the compression of the tablet also will improve.

 

2. Dryness

This is also a standard problem that is faced within the formulation of the tablets.

Cause: When the moisture content of the tablet is kept very low, it results in dryness of the tablet. The dryness leads to the weak bonding of the granules which can cause the tablets to disintegrate or create fractures within the cap.

Remedies: Adjust the moisture content so that tablets aren't too dry and not too wet. there's no specific percentage of moisture content needed to form a tablet. It depends on the number of water which can be needed to bond the granules together. So, the moisture content must be perfect.

 

3. Upper Punch Penetration

This is a capping problem that emanates from the machine.

Cause: It happens when the penetration controls for the tablet aren't set consistent with the perfect conditions. the perfect range of the control is from 1.5 mm to 2 mm. the most explanation for this problem is that the entrapped air. When the air is punched too deep within the die, it'll not have enough space to flee from the tablet, which can later form fractures within the tablet.

Remedies: you'll change the punching levels of the machine i.e. set punch penetration to three mm or less. you'll use tapered dies.

 4. Pre-compression

This problem is additionally found in machine controls and is caused by machine operators performing on the tablet press.

Cause: Pre-compression is employed to get rid of the entrapped air within the tablet which we discussed earlier. However, an excessive amount of pre-compression will cause the manufacturing of thin tablets. Too thin thickness can cause fractures or the creation of another layer of the tablet.

Remedies: The pre-compression values or controls of the machine should be changed accordingly.

 5. Tooling

Tooling is caused by using wrong controls within the machine. it's of varied kinds like a flat-faced, extra deep, shallow, modified ball, and far more.

Causes: When the upper punch cup of the tablet curls inward, it's called j-hooking. This phenomenon can pull the tablet apart. It happens when the upper punch of the cap isn't polished properly.

Remedies: Polish the tablet surface properly. you'll also use tapered dies.

The Causes and Remedies of Capping related to ‘Formulation




The Causes and Remedies of Capping related to ‘Machine'












 

Labels:
Location: New Jersey, USA

Comments

Post a Comment

Popular posts from this blog

Causes and Solution of Sticking of Tablet

Sticking is a multifactorial problem so that one single “fix” is unlikely to solve it completely, and “solutions” addressing one problem may exacerbate another. A broad-based strategy involving the API, formulation, tablet tooling and the manufacturing process is the most likely to provide robust and lasting solution. Sticking, an extension of filming, occurs when multiple layers of material adhere to the punch. In this text, we will use sticking to address all the areas where unwanted adherence of material to the punch occurs The tablet production process has become more simplified and more mechanized with the event of technology. However, the complexity of the tablet punching process has increased. But relatively the issues related to the tablet manufacturing process haven't yet been significantly reduced. Research has revealed that tablet processing problems are often because of the issues mostly found either within the formulation or within the compression. Sticking is one of t
Post a Comment
Read more

CONTINUED PROCESS VERIFICATION

What is Continued Process Verification (CPV) ? Continued Process Verification (CPV) is part of the FDA guidelines on Process Validation with a product lifecycle concept. The guideline is also an integration of the International Conference on Harmonisation (ICH) guidance for industry Q8 (Pharmaceutical Development), Q9 (Quality Risk Management) and Q10 (Pharmaceutical Quality Systems) Continued Process Verification The lifecycle concept links product and process development, qualification of the commercial manufacturing process, and maintenance of the process in a state of control during routine commercial production Process Validation is defined as the collection and evaluation of data, from the process design stage through commercial production, which establishes scientific evidence that a process is capable of consistently delivering quality product. The FDA guidance describes process validation in three stages: CPV • Stage 3 CPV is the process by which we verify that our product co
Post a Comment
Read more

Principle of HPLC (High Performance Liquid Chromatography)

  HPLC - A method for biochemical research HPLC stands for High Performance Liquid Chromatography. It is used for both preparative and analytical material separations. HPLC is particularly helpful for biochemistry in the preparation and analysis of substances with high molecular weights such as proteins.   What is liquid chromatography? Chromatography is a separation process in which a mixture of substances is separated using two phases, a stationary and a mobile phase. When talking about liquid chromatography, the stationary phase is a solid and the mobile phase is a liquid. It is called the eluent.   The mobile phase moves past the stationary phase and the mixture to be separated is delayed in its passage according to the interactions between the respective substance and the stationary phase and thus separated.   Various substances can serve as the stationary phase: In paper chromatography, these are special filter papers; for column and thin-layer chromatography, sil
Post a Comment
Read more