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Capping Tablet and its solution

The cases of tablet failure can be separated into two kinds: capping and lamination. In the case of biconvex tablets, capping corresponds to the separation of at least one of the two cups of the tablets whereas lamination corresponds to a failure in the band of the tablet. This article is focused on capping and its solution.

Capping is the upper or lower segment of the tablet separates horizontally, either partially or completely from the main body, and comes off like a cap, during ejection from the tablet press, or during subsequent handling. The common factors which can cause tablet capping; formulation related, excipient-related and machine-related.

Major causes of capping tablet and remedies for them

1. Fines

This is the matter faced within the formulation of the granules. Fines are small dust particles that are found within the tablets. These particles don't compress or flow alright and as a result, the tablet faces many problems.


Capping in Tablets

Cause: the variety of fines within the granules are quite the traditional amount. If the quantity of fines increases within the granules, it can further end in weight variation and segregation during compression of the tablet. this may cause improper flow or may be blockage of the flow of air.

Remedies: you would like to get rid of all or a number of the fines by using 100 to 200 mesh screens. By removal of fine particles, the air will flow properly within the tablet and therefore the compression of the tablet also will improve.

 

2. Dryness

This is also a standard problem that is faced within the formulation of the tablets.

Cause: When the moisture content of the tablet is kept very low, it results in dryness of the tablet. The dryness leads to the weak bonding of the granules which can cause the tablets to disintegrate or create fractures within the cap.

Remedies: Adjust the moisture content so that tablets aren't too dry and not too wet. there's no specific percentage of moisture content needed to form a tablet. It depends on the number of water which can be needed to bond the granules together. So, the moisture content must be perfect.

 

3. Upper Punch Penetration

This is a capping problem that emanates from the machine.

Cause: It happens when the penetration controls for the tablet aren't set consistent with the perfect conditions. the perfect range of the control is from 1.5 mm to 2 mm. the most explanation for this problem is that the entrapped air. When the air is punched too deep within the die, it'll not have enough space to flee from the tablet, which can later form fractures within the tablet.

Remedies: you'll change the punching levels of the machine i.e. set punch penetration to three mm or less. you'll use tapered dies.

 4. Pre-compression

This problem is additionally found in machine controls and is caused by machine operators performing on the tablet press.

Cause: Pre-compression is employed to get rid of the entrapped air within the tablet which we discussed earlier. However, an excessive amount of pre-compression will cause the manufacturing of thin tablets. Too thin thickness can cause fractures or the creation of another layer of the tablet.

Remedies: The pre-compression values or controls of the machine should be changed accordingly.

 5. Tooling

Tooling is caused by using wrong controls within the machine. it's of varied kinds like a flat-faced, extra deep, shallow, modified ball, and far more.

Causes: When the upper punch cup of the tablet curls inward, it's called j-hooking. This phenomenon can pull the tablet apart. It happens when the upper punch of the cap isn't polished properly.

Remedies: Polish the tablet surface properly. you'll also use tapered dies.

The Causes and Remedies of Capping related to ‘Formulation




The Causes and Remedies of Capping related to ‘Machine'












 

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Location: New Jersey, USA

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